Salt Overload & the Gut–Brain Axis

"Interestingly, there is a growing body of work showing that there is

communication between the gut and brain, now commonly dubbed the gut–brain axis. 

The disruption of the gut–brain axis contributes to a diverse range of diseases, including Parkinson’s disease and irritable bowel syndrome.

Consequently, the developing field of gut–brain axis research is rapidly growing. In 2013, a couple of studies showed that high salt intake leads to profound immune changes in the gut, resulting in increased vulnerability of the brain to autoimmunity—when the immune system attacks its own healthy cells and tissues by mistake, suggesting that perhaps the gut can communicate with the brain via immune signaling.

Research published in “Nature Neuroscience” shows another

connection: immune signals sent from the gut can compromise the brain’s blood vessels, leading to deteriorated brain heath and cognitive impairment. 

Surprisingly, the research unveils a previously undescribed gut–brain connection mediated by the immune system and indicates that excessive salt might negatively impact brain health in humans through impairing the brain’s blood vessels regardless of its effect on blood pressure.

This research proposes new therapeutic targets for countering stroke—the second leading cause of death worldwide—and cognitive dysfunction. 

Reducing salt intake is applicable to people around the globe, as nearly every adult consumes too much salt: on average 9–12 grams per day or around twice the recommended maximum level of intake (5 grams) by the World Health Organization.

The researchers used mice, and found that immune responses in the

small intestines set off a cascade of chemical responses reaching the brain’s blood vessels, reducing blood flow to the cortex and hippocampus, two brain regions crucial for learning and memory. This, in turn, brought a decline in tests of cognitive performance. 

The impairment in learning and memory was clear even in the absence of high blood pressure; they observed that the gut is reacting to the salt overload and directing immune signals that lay the basis for deterioration throughout the brain’s vital vascular complex and compromise cognitive function. 

Lowering salt intake has been shown to have beneficial effects to

overall health, so the researchers wanted to know whether these effects extend to this newly identified signaling cascade that begins in the gut and targets the brain’s blood vessels to, ultimately, affect cognitive function. 

*When the mice were returned to a normal diet after being on a high salt diet, the detrimental health effects caused by excess salt intake were erased.

The implications of this newly identified gut–brain connection
extend to several autoimmune disorders, including multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease, that have been shown to activate the same immune signaling pathway implicated in this study. These autoimmune disorders have a high stroke risk and are linked to poorly functioning blood vessels in the nervous system." 

ScientificAmerican